Sporogenics products are currently focusing on wound-healing and postoperative adhesions prevention, and they are available in two forms: film and microgel.
Adhesions are fibrinous bands of internal scar tissue that can cause internal tissues and organs that are normally separated to stick together. Peritoneal adhesions have been a recurring post-operation complication that have existed till today as a painful and traumatic experience for many patients today. Up to 93% of patients develop adhesions following initial laparotomy [1,2]. Modern medical science has yet to reach 100% reduction or prevention with the current gold standard of placement of adhesion barrier film or anti-fibrinolytic agents administered locally at the healing sites. Adhesion barrier films from established medical device companies have reached a plateau at the 50-60% prevention mark, nevertheless some with reportable adverse events to date.
Based on in-vitro studies, Sporogenics has identified a unique anti-fibrinolytic and anti-inflammatory characteristics in a plant-derived biopolymer. This naturally derived biopolymer contains an abundance of bioactive ingredients which specifically attenuate the cellular mechanism and signaling pathway of fibrogenesis and inflammation. Similar claims by other bioactive agents have been well supported by past scientific reports. For instance, gallic acid, a type of phenolic acid, has been shown to attenuate postoperative adhesion in animal studies . Other phenolic acids and phenolic complexes have also been shown to exhibit immunomodulatory and cellular antioxidant activities, all play a significant role in the formation of postoperative adhesion .
Our team has patented the extraction technology to form a biopolymer microgel that passed ISO 10993-11 material-mediated pyrogenicity test. Sporogenics has successfully prototyped the manufacturing of the biopolymer film. We have thus implanted our prototype in rat models to validate the combined physical mode of action in combination with adjuvant bioactive mechanism. Within a span of 28 days we observed no cytotoxicity and complete absence of adhesion in the animals post-surgical procedures. We are exhilarated by our findings and are currently in pursuit of a larger scale animal studies.
1. Becker JM, Dayton MT, Fazio VW, et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg. 1996;183(4):297-306.
2. Menzies D, Ellis H. Intestinal obstruction from adhesions—how big is the problem? Ann R Coll Surg Engl. 1990;72(1):60-63.
3. Guangbing Wei, Yunhua Wu, Qi Gao, et. al. Gallic acid attenuates postoperative intra-abdrominal adhesion by inhibiting inflammatory reaction in a rat model, Med Sci Monit, 2018; 24: 827-838.
4. Soumaya Kilani-Jaziri et. al. Immunomodulatory and cellular anti-oxidant activities of caffeic, ferulic, and p-coumaric phenolic acids:
a structure-activity relationship study. Drug and Chemical Toxicology 2017; 40:4: 525-6014 (online).